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KMID : 0370220040480010060
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Yakhak Hoeji
2004 Volume.48 No. 1 p.60 ~ p.64
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Nondestructive Quantification of Intact Ambroxol Tablet using Near-infrared Spectroscopy
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임현량/Lim HR
우영아/김도형/김효진/강신정/최현철/최한곤/Woo YA/Kim DH/Kim HJ/Kang SJ/Choi HC/Choi HG
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Abstract
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Near-infrared (NIR) spectroscopy was used to determine rapidly and nondestructively the content of ambroxol in intact ambroxol tablets containing 30 mg (12.5% m/m nominal conc entration) by collecting NIR spectra in range 1100~1750 nm. The laboratory-made samples had 10.3~15.9% m/m nominal ambroxol concentration. The measurements were made by reflection using a fiber-optic probe and calibration was carried out by partial least square regression (PLSR) with autoscaling. Model validation was performed by randomly splitting the data set into calibration and validation data set (7 samples as a calibration data set and 5 samples as a validation data set). The developed NIR method gave results comparable to the known values of tablets in a laboratorial manufacturing process, standard error of calibration (SEC) and standard error of prediction (SEP) being 0.49% and 0.49% m/m respectively. The method showed good accuracy and repeatability, NIR spectroscopic determination in intact tablets allowed the potential use of real time monitoring for a running production process.
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KEYWORD
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